The Understanding the Agents Used to Treat Acute Lymphoblastic Leukemia learning program is designed to introduce the agents used to treat acute lymphoblastic leukemia (ALL) and the cellular processes these agents target. The variety of therapeutic agents used reflects the diversity of cellular processes that can be exploited as a therapeutic target for ALL. This program will first introduce the different phases of ALL treatment followed by the different potential therapeutic agents along with the cellular processes they target including gene activity cell division protein synthesis DNA replication and intracellular signal transduction. The program will also cover the mechanisms of action and of resistance for each therapeutic agent as well as additional therapies for ALL including supportive and palliative care and stem cell transplantatio
Upon completion of this learning program you will be able to::
List the agents that are used in the treatment of ALL.
Identify the therapeutic targets of the agents used in the treatment of ALL.
Describe the proposed mechanisms of action of the agents used in the treatment of ALL.
Describe the mechanisms responsible for the development of resistance to the agents used in the treatment of ALL.
Recall additional therapies used in the context of ALL, including supportive therapies, stem cell transplantation, and palliative care.
INTRODUCTION TO ALL TREATMENT
REGULATION OF GENE ACTIVITY
HOW IS GENE ACTIVITY REGULATED?
THERAPY – GLUCOCORTICOIDS
INHIBITION OF CELL DIVISION
WHAT IS CELL DIVISION?
THERAPY – VINCA ALKALOIDS
INDUCTION OF DNA DAMAGE
WHAT IS DNA DAMAGE?
THERAPY – ANTHRACYCLINES
THERAPY – EPIPODOPHYLLOTOXINS
THERAPY – ALKYLATING AGENTS
INHIBITION OF PROTEIN SYNTHESIS
WHAT IS PROTEIN SYNTHESIS?
THERAPY – ASPARAGINASE
INHIBITION OF DNA REPLICATION
WHAT IS DNA REPLICATION?
THERAPY – METHOTREXATE
THERAPY – NUCLEOSIDE ANALOGUES
INHIBITION OF INTRACELLULAR SIGNAL TRANSDUCTION
WHAT IS INTRACELLULAR SIGNAL TRANSDUCTION?
THERAPY – TYROSINE KINASE INHIBITORS
ADDITIONAL TREATMENTS FOR ALL
STEM CELL TRANSPLANTATION
TEST YOUR ACQUIRED KNOWLEDGE
END OF PROGRAM
This course is accredited for continuing education (CE) by the following organizations:
Australian Nursing & Midwifery Federation
CPD Hours: 1